Publications

Journal Publications and Book Chapters
 
2009 back to top
  1. Carsillo, M., Kutala, V.K., Puschel, K., Blanco, J., Kuppusamy, P., Niewiesk, S. Nitric oxide production and nitric oxide synthase type 2 expression by cotton rat (Sigmodon hispidus) macrophages reflect the same pattern as human macrophages. Dev Comp Immunol. Epub ahead of print. [PubMed]
  2. Mohan, I. K., Khan, M., Wisel, S., Selvendiran, K., Sridhar, A., Carnes, C. A., Bognar, B., Kalai, T., Hideg, K., Kuppusamy, P. Cardioprotection by HO-4038, a Novel Verapamil Derivative, Targeted against Ischemia and Reperfusion-mediated Acute Myocardial Infarction. Am J Physiol. Heart Circ. Physiol 296, H140-H151 (2009). [PubMed]
 
2008 back to top
  1. Ahmad, R., Potter, L., Vikram, D. and Kuppusamy, P. Estimation of mean and median pO2 values for a composite EPR spectrum. J. Magn. Reson. 192, 269-274 (2008). [PubMed]
  2. Bratasz, A., Selvendiran, K., Tong, L., Tomasz, T., Bobko, A., Khramtsov, V. V., Ignarro, L. J., and Kuppusamy, P. NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols. J. Translational Medicine 6, 9 (12 pages) (2008). [PubMed]
  3. Eteshola E, Pandian RP, Lee SC, Kuppusamy P. Polymer coating of paramagnetic particulates for in vivo oxygen-sensing applications. Biomedical Microdevices 2008. [PubMed]
  4. Hussain, S.A., Lucas, D. M., Johnson, AJ, Lin, TS, Viatchenko-Karpinski, S., Bakaletz, AP, Dang, V, Kuppusamy, P., Crouser, E. D., Byrd, JC, Grever, MR. Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with loss of oxygen consumption and mobilization of intracellular calcium. Blood 111, 3190-3199 (2008). [PubMed]
  5. Khan, M., Kutala, V. K., Wisel, S., Chacko, S. M., Kuppusamy, M. L., Kwiatkowski, P., Kuppusamy, P. Measurement of oxygenation at the site of stem cell therapy in a murine model of myocardial infarction. Adv. Exp. Med. Biol. 614, 45-52 (2008). [PubMed]
  6. Khan, M., Iyyapu, K.M., Kutala, V., Kotha, S., Parinandi, N.L., Hamlin, R.L., Kuppusamy, P., Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS leading to enhancement of nitric-oxide bioavailability and tissue oxygenation. Antiox. Redx Signal. 2008
  7. Epub ahead of print. [PubMed]
    Kulkarni, A. C., Bratasz, Rivera, B. K, Krishna, M. C. Kuppusamy, P. Redox Mapping of Biological Samples Using EPR Imaging. Israel J Chem. 48, 27-31 (2008).
  8. Kutala, V. K., Villamena, F. A., Ilangovan, G., Maspoch, D., Roques, N., Veciana, J., Rovira, C., Kuppusamy, P. Reactivity of superoxide anion radical with a perchlorotriphenylmethyl (trityl) radical. J. Phys. Chem. B. 112, 158-167 (2008). [PubMed]
  9. Matsumoto, S., Espey, M. G., Utsumi, H., Devasahayam, N., Matsumoto, K-I., Matsumoto, A., Hirata, H., Wink, D. A., Kuppusamy, P.,  Subramanian, S., Mitchell, J. B., and Krishna, M. C. Dynamic monitoring of localized tumor oxygenation changes using RF pulsed electron paramagnetic resonance in conscious mice. Magn. Reson. Med. 59, 619-625 (2008). [PubMed ]
  10. Ojha, N. Roy, S., Radtke, J., Simonetti, O., Gnyawali, S., Zweier, J., Kuppusamy, P., and Sen, C. K., Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury. Am J. Physiol Heart Circul Phys. 294, H2435-H2543 (2008). [PubMed]
  11. Ojha, N., Roy, S., He, G., Biswas, S., Velayutham, M., Khanna, S., Kuppusamy, P., Zweier, J. L., and Sen, C. K. Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing. Free Radic. Biol. Med. 44, 682-691 (2008). [PubMed]
  12. Roshchupkina, G. I., Bobko, A. A., Bratasz, A., Reznikov, V. A., Kuppusamy, P.  In vivo EPR measurement of glutathione in tumor-bearing mice using improved disulfide biradical probe. Free Radic. Biol. Med. 45, 312 - 320 (2008). [PubMed]
  13. Savla, M., Pandian, R. P., Kuppusamy, P. Agarwal, G. Magnetic Force Microscopy of an Oxygen-Sensing Spin-Probe. Israel J Chem. 48, 33-38 (2008).
  14. Selvendiran, K., Bratasz, A., Tong, L. Ignarro, L. J., and Kuppusamy, P. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle 7, 81-88 (2008). [PubMed]
  15. Steinhour E, Sherwani SI, Mazerik JN, Ciapala V, O'Connor Butler E, Cruff JP, Magalang U, Parthasarathy S, Sen CK, Marsh CB, Kuppusamy P, Parinandi NL. Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase. Mol Cell Biochem. 315: 97-112 (2008). [PubMed]
  16. Subramaniam, D., May, R. Sureban, S., Lee, K. B., George, R., Kuppusamy, P., Ramanujam, R. P., Hideg, K., Diekgraefe, B. K., Houchen, C. W., Anant, S. Diphenyl difluroketone (ef24): a curcumin derivative with potent in vivo anti-cancer activity. Cancer Research 68, 1962-1969 (2008). [PubMed]
  17. Vikram DS, Ahmad R, Pandian RP, Petryakov S, Kuppusamy P. Evaluation of oxygen-response times of phthalocyanine-based crystalline paramagnetic spin probes for EPR oximetry. J Magn Reson. 193: 127-132 (2008). [PubMed]
  18. Som, S., Potter, L. C., Ahmad, R., Vikram, D. S., Kuppusamy, P. EPR oximetry in three spatial dimensions using sparse spin distribution. J. Magn. Reson. 193, 210-217 (2008). [PubMed]
  19. Vikram, D. S., Ahmad, R., Rivera, B. K., Kuppusamy, P. Mapping of Oxygen Concentration in Biological Samples Using EPR Imaging. Israel J Chem. 48, 39-43 (2008).
 
2007 back to top
  1. Ahmad, R., Clymer, B., Vikram, D. S., Deng, Y., Hirata, H., Zweier, J. L., Kuppusamy, P. Enhanced resolution for EPR imaging by two-step deblurring. J Magn Reson 184:246-257 (2007). [PubMed]
  2. Ahmad, R., Deng, Y., Vikram, D. S., Clymer, B., Srinivasan, P., Zweier, J. L., Kuppusamy, P. Quasi Monte Carlo-based isotropic distribution of gradient directions for improved reconstruction quality of 3D EPR imaging. J Magn Reson 184:236-245 (2007). [PubMed]
  3. Ahmad, R., Vikram, D. S., Clymer, B., Potter, L. C., Deng, Y., Srinivasan, P., Zweier, J. L., Kuppusamy, P. Uniform distribution of projection data for improved reconstruction quality of 4D EPR imaging. J Magn Reson 187:277-287 (2007). [PubMed]
  4. Bratasz, A., Kulkarni, A. C., Kuppusamy, P. A highly sensitive biocompatible spin probe for imaging of oxygen concentration in tissues. Biophys J 92:2918-2925 (2007). [PubMed]
  5. Bratasz, A., Pandian, R. P., Deng, Y., Petryakov, S., Grecula, J. C., Gupta, N., Kuppusamy, P. In vivo imaging of changes in tumor oxygenation during growth and after treatment. Magn Reson Med 57:950-959 (2007). [PubMed]
  6. Bratasz, A. and Kuppusamy, P. Mapping tumor hypoxia using magnetically labeled cells. Ind. J. Rad. Research, 4, 144-151 (2007).
  7. Butt, O. I., Carruth, R., Kutala, V. K., Kuppusamy, P., Moldovan, N. I. Stimulation of Peri-Implant Vascularization with Bone Marrow-Derived Progenitor Cells: Monitoring by In Vivo EPR Oximetry. Tissue Eng, 13(8), 2053-2061 (2007). [PubMed]
  8. Dang, V., Wang, J., Feng, S., Buron, C., Villamena, F. A., Wang, P. G., Kuppusamy, P. Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: a potential sensor for superoxide and oxygen in biological systems. Bioorg Med Chem Lett 17:4062-4065 (2007). [PubMed]
  9. Deng, Y., Petryakov, S., He, G., Kesselring, E., Kuppusamy, P., Zweier, J. L. Fast 3D spatial EPR imaging using spiral magnetic field gradient. J Magn Reson 185:283-290 (2007). [PubMed]
  10. Fujii, H., Itoh, K., Pandian, R. P., Sakata, M., Kuppusamy, P., Hirata, H. Measuring Brain Tissue Oxygenation under Oxidative Stress by ESR/MR Dual Imaging System. Magn Reson Med Sci 6:83-89 (2007). [PubMed]
  11. Hagele, T. J., Mazerik, J. N., Gregory, A., Kaufman, B., Magalang, U., Kuppusamy, M. L., Marsh, C. B., Kuppusamy, P., Parinandi, N. L. Mercury activates vascular endothelial cell phospholipase D through thiols and oxidative stress. Int J Toxicol 26:57-69 (2007). [PubMed]
  12. Isenberg, J. S., Hyodo, F., Matsumoto, K., Romeo, M. J., Abu-Asab, M., Tsokos, M., Kuppusamy, P., Wink, D. A., Krishna, M. C., Roberts, D. D. Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation. Blood 109:1945-1952 (2007). [PubMed]
  13. Khan, M., Kutala, V. K., Mohan, I. K., Kumbala, D., and Kuppusamy P. Cardioprotection by sulfaphenazole, a cytochrome P450 inhibitor: Mitigation of ischemia-reperfusion injury by scavenging of reactive oxygen species. J. Pharmacol. Exper. Therap. 323, 813-821 (2007). [PubMed]
  14. Khan, M., Kutala, V. K., Wisel, S., Chacko, S. M., Kuppusamy, M. L., Kwiatkowski, P., Kuppusamy, P. Measurement of oxygenation at the site of stem cell therapy in a murine model of myocardial infarction. Adv. Exp. Med. Biol. 1-6 (2007).
  15. Khan, M., Kutala, V. K., Vikram, D. S., Wisel, S., Chacko, S. M., Kuppusamy, M. L., Mohan, I. K., Zweier, J. L., Kwiatkowski, P., Kuppusamy, P. Skeletal Myoblasts Transplanted in the Ischemic Myocardium Enhance In Situ Oxygenation and Recovery of Contractile Function. Am J Physiol Heart Circ Physiol; 293, H2129-H2139 (2007). [PubMed]
  16. Kulkarni, A., Kuppusamy, P., Parinandi, N. L., Oxygen, the lead actor in the pathophysiologic drama: Enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy. Antiox. Redox Signal. 9(10), 1717-1730 (2007). [PubMed]
  17. Kutala VK, Parinandi NL, Khan M, Iyyapu KM, Kuppusamy P. Spirulina - A Blue-green Alga with Novel Therapeutic Actions. Recent Progress in Medicinal Plants, Volume 22, Editor J.N. Govil, Stadium Press LLC, P.O. Box 722200, Houston, Texas (2007).
  18. Kutala, V. K., Mohan, I. K., Khan, M., Parinandi, N. L., Kuppusamy, P. Drug-induced nephrotoxicity protection by Spirulina: Spirulina in Human Health and Nutrition. In Spirulina in Human Nutrition and Health, Editors: Gershwin E and Belay A, CRC Press, Taylor & Francis Group, Boca Raton, FL. 151-172 (2007).
  19. Kutala, V. K., Khan, M., Angelos, M. G., Kuppusamy, P. Role of oxygen in postischemic myocardial injury. Antioxid Redox Signal 9:1193-1206 (2007). [PubMed]
  20. Mandal, R., Kutala, V. K., Khan, M., Mohan, I. K., Varadharaj, S., Sridhar, A., Carnes, C. A., Kalai, T., Hideg, K., Kuppusamy, P. N-hydroxy-pyrroline Modification of Verapamil Exhibits Antioxidant Protection of the Heart against Ischemia/Reperfusion-induced Cardiac Dysfunction without compromising its Calcium Antagonistic Activity. J Pharmacol Exp Therap 323, 119-127 (2007). [PubMed]
  21. Mazerik J.N., Hagele T, Sherwani S, Ciapala V, Butler S, Kuppusamy M.L., Hunter M, Kuppusamy P, Marsh C.B., Parinandi N.L.. Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells. Am. Coll.Toxicol. J. 26, 553-569 (2007). [PubMed]
  22. Mazerik J.N., Mikkilineni H, Kuppusamy V.A., Steinhour E, Peltz A, Marsh, C.B., Kuppusamy P, Parinandi, N.L., Mercury activates phospholipase A2 and induces formation of arachidonic acid metabolites in vascular endothelial cells. Toxicol. Mech. Methods 17, 1-17 (2007).
  23. Pandian, R. P., Dolgos, M., Dang, V., Sostaric, J. Z., Woodward, P. M., Kuppusamy, P. Structure and oxygen-sensing paramagnetic properties of a new lithium 1,8,15,22-tetraphenoxyphthalocyanine radical probe for biological oximetry. Chem. Mater. 19:3545-3552 (2007).
  24. Parinandi, N.L., Sharma, A., Eubank, T. D., Kaufman, B., Kutala, V. K., Marsh, C. B., Ignarro, L. J., Kuppusamy, P. Nitroaspirin (NCX-4016), an NO donor, is antiangiogenic through induction of loss of redox-dependent viability and cytoskeletal reorganization in endothelial cells. Antiox. Redox Signal. 9(11): 1837 - 1849 (2007). [PubMed]
  25. Selvendiran, K., Tong, L., Vishwanath, S., Bratasz, A., Trigg, N. J., Kutala, V. K., Hideg, K., Kuppusamy, P. EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. J Biol Chem; 282, 28609-28618 (2007). [PubMed]
  26. Som, S., Potter, L. C., Ahmad, R., Kuppusamy, P. A parametric approach to spectral-spatial EPR imaging. J Magn Reson 186:1-10 (2007). [PubMed]
  27. Sostaric, J. Z., Pandian, R. P., Bratasz, A., Kuppusamy, P. Encapsulation of a highly sensitive EPR active oxygen probe into sonochemically prepared microspheres. J Phys Chem B 111:3298-3303 (2007). [PubMed]
  28. Steinhour, E., Ciapala, V., Butler, S., Mazerik, J. N., Kuppusamy, P., Magalang, U., Parthasarathy, S., Marsh, C. B., Sen, C. K., Parinandi, N. L. Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: Vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase. Free Radicals and Antioxidant Protocols,  Editors: Rao M. Uppu, Subramanyam N. Murthy, and William A. Pryor, 2nd Edition for Methods in Mol Biol Series, Humana Press, Totowa, NJ (2007).
  29. Turakhia, S., Venkatakrishnan, C. D., Dunsmore, K., Wong, H., Kuppusamy, P., Zweier, J. L., and Ilangovan, G. Doxorubicin-induced cardiotoxicity: Direct correlation of cardiac fibroblasts and H9C2 cell survival and aconitase activity with heat shock protein-27. Am. J. Physiol. Heart Circ. Physiol. 293, H3111-H3121 (2007). [PubMed]
  30. Velan, S. S., Lemieux, S. K., Raylman, R. R., Boling, W., Hobbs, G. R., Spencer, R. G., Sridhar, R., Kuppusamy, P., Thomas, M. A. Detection of cerebral metabolites by single-voxel-based PRESS and COSY techniques at 3T. J Magn Reson Imaging 26:405-409 (2007). [PubMed]
  31. Vikram, D. S., Rivera, B. K., Kuppusamy, P. In vivo imaging of free radicals and oxygen. Methods in Molecular Biology (2007).
  32. Vikram, D. S., Bratasz, A., Ahmad, R., Kuppusamy, P. A comparative evaluation of EPR and OxyLite oximetry using a random sampling of pO2 in a murine tumor. Radiat. Research 168: 308-315 (2007). [PubMed]
  33. Vikram, D. S., Zweier, J. L., Kuppusamy, P. Methods for Noninvasive Imaging of Tissue Hypoxia. Antioxid Redox Signal; 9(10) 1745-1756 (2007). [PubMed]
  34. >Weir, N. M., Selvendiran, K., Kutala, V. K., Tong, L., Vishwanath, S., Rajaram, M., Tridandapani, S., Anant, S., Kuppusamy, P. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther 6:178-184 (2007). [PubMed]
  35. Wisel, S., Chacko, S. M., Kuppusamy, M. L., Pandian, R. P., Khan, M., Kutala, V. K., Burry, R. W., Sun, B., Kwiatkowski, P., Kuppusamy, P. Labeling of skeletal myoblasts with a novel oxygen-sensing spin probe for noninvasive monitoring of in situ oxygenation and cell therapy in heart. Am J Physiol Heart Circ Physiol 292:H1254-H1261 (2007). [PubMed]
  36. Yang, L., Sostaric, J. Z., Rathman, J. F., Kuppusamy, P., Weavers, L. K. Effects of pulsed ultrasound on the adsorption of n-alkyl anionic surfactants at the gas/solution interface of cavitation bubbles. J Phys Chem B 111:1361-1367 (2007). [PubMed]
 
2006 back to top
  1. Ahmad, R., Clymer, B., Deng, Y., He, G., Vikram, D., Kuppusamy, P., Zweier, J. L., Optimization of data acquisition for EPR imaging. J. Magn. Reson. 179, 263-272 (2006). [PubMed]
  2. Ahmad, R., Vikram, D., Petryakov, S., Deng, Y., Zweier, J. L., Kuppusamy, P., Clymer, B. Automated on-the-fly detection and correction procedure for imaging data acquisition. Magn. Reson. Med. 56, 644-653 (2006). [PubMed]
  3. Angelos, M. G., Kutala, V. K., Torres, C. A., He, G., Stoner, J. D., Mohammad, M., Kuppusamy, P. Hypoxic reperfusion of the ischemic heart and oxygen radical generation. Am. J. Physiol. (Heart Circ. Physiol.) 290, H341-H347 (2006). [PubMed]
  4. Bratasz, A., Ilangovan, G., Pandian, R. P., and Kuppusamy, P. Monitoring oxygenation during the growth of a transplanted tumor. Adv. Exp. Med. Biol., 578, 375-380 (2006). [PubMed]
  5. Bratasz, A., Weir, N. M., Parinandi, N. L., Zweier, J. L., Sridhar, R., Ignarro, L. J., and Kuppusamy, P. Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro-derivative of aspirin. Proc. Natl. Acad. Sci. USA 103, 3914-3919 (2006). [PubMed]
  6. Deng, Y., Pandian, R. P., Ahmad, R., Kuppusamy, P., Zweier, J. L. Application of magnetic field over-modulation for improved EPR linewidth measurements using probes with Lorentzian lineshape. J. Magn. Reson. 181, 254-261 (2006). [PubMed]
  7. Deng, Y., Shet, K., Li, H., Kuppusamy, P., Zweier, J. L. Real-time calculation and visualization of spectra in field-cycled dynamic nuclear polarization spectroscopy. J. Comput. Methods. Program. Biomed. 82, 67-72 (2006). [PubMed]
  8. Ganesan, L. P., Joshi, T., Fang, H., Kutala, V. K., Roda, J., Trotta, R., Lehman, A., Kuppusamy, P., Byrd, J. C., Carson, W. E., Caligiuri, M. A., Tridandapani, S. FcgammaR-induced production of super oxide and inflammatory cytokines is differentially regulated by SHIP through its influence on P13K and/or Ras/Erk pathways. Blood 108, 718-725 (2006). [PubMed]
  9. Ilangovan, G., Venkatakrishnan, C. D., Bratasz, A., Osinbowale, S., Cardounel, A. J., Zweier, J. L., and Kuppusamy, P. Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9C2 cells. Am. J. Physiol. (Cell Physiol.) 290, C313-C324 (2006). [PubMed]
  10. Kalai, T., Khan, M., Balog, M., Kutala, V. K., Kuppusamy, P., and Hideg, K. Structure-activity studies on the protection of Trimetazidine derivatives modified with nitroxides and their precursors from myocardial ischemia-reperfusion injury. Bio-org. Med. Chem. 14, 5510-5516 (2006). [PubMed]
  11. Khan, M., Varadharaj, S., Ganesan, L. P., Shobha, J. C., Naidu, M. U., Parinandi, N. L., Tridandapani, S., Kutala, V. K., Kuppusamy, P. C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling. Am. J. Physiol. Heart. Circ. Physiol. 290, H2136-2145 (2006). [PubMed]
  12. Khan, M., Varadharaj, S., Shobha, J. C., Naidu, M. U., Parinandi, N. L., Kutala, V. K., and Kuppusamy, P. C-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytes. J. Cardiovasc. Pharmacol. 47, 9-20 (2006). [PubMed]
  13. Kutala, V. K., Khan, M., Mandal, R., Ganesan, L. P., Tridandapani, S., Kalai, T., Hideg, K., Kuppusamy, P. Attenuation of myocardial ischemia - reperfusion injury by trimetazidine derivatives functionalized with antioxidant properties. J. Pharmacol. Exp. Ther. 317, 921-928 (2006). [PubMed]
  14. Kutala, V. K., Khan, M., Mandal, R., Potaraju, V., Colantuono, G., Kumbala, D., Kuppusamy, P. Prevention of post-ischemic myocardial reperfusion injury by the combined treatment of NCX-4016 and Tempol. J. Cardiovasc. Pharmacol. 48, 79-87 (2006). [PubMed]
  15. Li, H., He, G., Deng, Y., Kuppusamy, P., Zweier, J. L. In vivo proton electron double resonance imaging of the distribution and clearance of nitroxide radicals in mice. Magn. Reson. Med. 55, 669-675 (2006). [PubMed]
  16. Magalang, U., Rajappan, R., Hunter, M. G., Kutala, V. K., Kuppusamy, P., Wewers, M., Marsh, C. B., and Parinandi, N. L. Adiponectin inhibits superoxide generation by human neutrophils, Antiox. Redox Signal. 8, 2179-2186 (2006). [PubMed]
  17. Mohan, I. K., Khan, M., Shobha, J. C., Naidu, M. U., Prayag, A., Kuppusamy, P., Kutala, V. K. Protection against cisplatin-induced nephrotoxicity by Spirulina in rats. Cancer Chemother. Pharmacol. 58, 802-808 (2006). [PubMed]
  18. Pandian, R. P., Dang, V., Manoharan, P. T., Zweier, J. L., Kuppusamy, P. Effect of nitrogen dioxide on the EPR property of lithium octa-n-butoxy 2,3-naphthalocyanine ( LiNc-BuO ) microcrystals. J. Magn. Reson. 181, 154-161 (2006). [PubMed]
  19. Pandian, R. P., Kim, Y-I, Woodward, P., Zweier, J. L., Manoharan, P. T., and Kuppusamy, P. Open molecular framework in lithium octabutoxy-naphthalocyanine paramagnetic crystal: Implications for the detection of oxygen and nitric oxide by EPR spectroscopy. J. Mater. Chem. 16, 3609-3620 (2006).
  20. Parinandi, N. L., Sen, C. K., and Kuppusamy, P. Joint International Conference on EPR Spectroscopy and wound healing. Antiox. Redox Signal. 8, 1385-1387 (2006). [PubMed]
  21. Presley, T., Kuppusamy, P., Zweier, J. L., Ilangovan, G. Electron paramagnetic resonance oximetry as a quantitative method to measure cellular respiration: a consideration of oxygen diffusion interference. Biophys. J. 91, 4623-4631 (2006). [PubMed]
  22. Presley, T., Kuppusamy, P., Zweier, J. L., Ilangovan, G. The role of heat shock protein 90 and endothelial nitric oxide synthetase signaling in cardiovascular therapy. J. Current Signal Transduction Therapy. 1, 305-315 (2006).
  23. Sostaric, J., Pandian, R. P., Weavers, L. K., Kuppusamy, P. Ultrasound-induced miniaturization of micron-sized lithium phthalocyanine particles. Chem. Mater. 18, 4183-4189 (2006).
  24. Varadharaj, S., Steinhour, E., Hunter, M. G., Watkins, T., Baran, C. P., Magalang, U., Kuppusamy, P., Zweier, J. L., Marsh, C. B., Natarajan, V., Parinandi, N. L. Vitamin C-induced activation of phospholipase D in lung microvascular endothelial cells: Regulation by MAP kinases. Cell Signal. 18, 1396-1407 (2006). [PubMed]
  25. Venkatakrishnan, C. D., Tewari, A. K., Moldovan, L., Cardounel, A. J., Zweier, J. L., Kuppusamy, P., Ilangovan, G. Heat-shock protects cardiac cells from doxorubicin-induced toxicity by activating p38MAPK and phosphorylation of small heat-shock protein-27. Am. J. Physiol. (Heart Circ. Physiol.). 291, 2680-2691 (2006). [PubMed]
  26. Xia, S., Villamena, F. A., Hadad, C. M., Kuppusamy, P., Li, Y., Zhu, H., and Zweier, J. L. Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals. J. Org. Chem., 71, 7268-7279 (2006). [PubMed]
 
2005 back to top
  1. Bratasz, A. and Kuppusamy, P. Noninvasive imaging of oxygenation in a transplanted tumor. Current Topics in Biophysics , 29, 101-107 (2005).
  2. Deng Y., Kuppusamy, P, Zweier, J. L. Progressive EPR imaging with adaptive projection acquisition. J. Magn. Reson. 174, 177-187 (2005). [PubMed]
  3. Fries, R. B., Wallace, W. A., Roy, S., Kuppusamy, P., Bergdall, V., Gordillo, G. M., Melvin, S. M., Sen, C. K. Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen. Mutation Research. 579, 172-181 (2005). [PubMed]
  4. Ilangovan, G., Bratasz, A. and Kuppusamy, P. Noninvasive measurement of tumor oxygenation using embedded microparticulate EPR spin probe. Adv. Exp. Biol. Med. Oxygen Transport to Tissue XXVI, Okunieff, P., Williams, J., and Chen, Y. (Eds.), Springer, Volume, 566, (2005). [PubMed]
  5. Khan, M., Shobha, J. C., Mohan, I. K., Naidu, M. U., Sundaram, C., Singh, S., Kuppusamy, P., Kutala, V. K. Phytotherapy Research, 19, 1030-1037 (2005). [PubMed]
  6. Kutala, V. K. and Kuppusamy, P. Trityl radicals for quantitative detection of superoxide in biological systems. Current Topics in Biophysics, 29, 129-138 (2005).
  7. Matsumoto, A., Matsumoto, S., Sowers, A. L., Koscielniak, J. W., Trigg, N. J., Kuppusamy, P., Mitchell, J. B., Subramanian, S., Krishna, M. C., Matsumoto, K. Absolute oxygen tension (pO(2)) in murine fatty and muscle tissue as determined by EPR. Magn. Reson. Med. 54, 1530-1535 (2005). [PubMed]
  8. Pandian, R. P., Kutala, V. K., Liaugminas, A., Parinandi, N. L. and Kuppusamy, P. Lipopolysaccharide-induced alterations in oxygen consumption and radical generation in endothelial cells. Mol. Cell. Biochem. 278, 119-127 (2005). [PubMed]
  9. Tritto, I., Wang, P., Kuppusamy, P., Giraldez, R., Zweier, J. L., and Ambrosio, G. The anti-anginal drug trimetazidine reduces neutrophil-mediated cardiac reperfusion injury. J Cardiovasc Pharmacol. 46, 89-98 (2005). [PubMed]
  10. Varadharaj, S., Watkins, T., Cardounel, A. J., Garcia, J. G. N., Zweier, J. L., Kuppusamy, P., Natarajan, V., Parinandi, N. L. Vitamin C-induced loss of redox-dependent viability in lung microvascular endothelial cells, Antiox. Redox Signal. 7, 287-300 (2005). [PubMed]
  11. Xu, K., and Kuppusamy, P. Dual effects of copper-zinc superoxide dismutase. Biochem. Biophys. Res. Comm. 336, 1190-1193. (2005). [PubMed]
  12. Zhao, X., He, G., Chen, Y-R., Pandian, R. P., Kuppusamy, P., and Zweier, J. L. Endothelium-derived nitric oxide regulates postischemic myocardial oxygenation and oxygen consumption by modulation of mitochondrial electron transport. Circulation, 111, 2966-2972 (2005). [PubMed]
 
2004 back to top
  1. Crowther, J. E., Kutala, V. K., Kuppusamy, P., Ferguson, J. S., Beharka, A. A., Zweier, J. L., McCormack, F. X., and Schlesinger, L. S. Pulmonary surfactant protein A inhibits macrophage reactive oxygen intermediate production in response to stimuli by reducing NADPH oxidase activity. J. Immunol. 172, 6866-6874 (2004). [PubMed]
  2. Deng, Y., He, G., Petryakov, S., Kuppusamy, P., and Zweier, J. L. Fast EPR imaging at 300 MHz using spinning magnetic field gradients. J. Magn. Reson. 168, 220-227 (2004). [PubMed]
  3. He, G., Kutala, V. K., Kuppusamy, P., and Zweier, J. L. In vivo measurement and mapping of skin redox stress induced by ultraviolet light exposure. Free Radic. Biol. Med. 36, 665-672 (2004). [PubMed]
  4. Ilangovan, G., Liebgott, T., Kutala, V. K., Petryakov, S., Zweier, J. L., and Kuppusamy, P. EPR oximetry in the beating heart: Myocardial oxygen consumption rate as an index of postischemic recovery. Magn. Reson. Med. 51, 835-842 (2004). [PubMed]
  5. Ilangovan, G., Zweier, J. L., and Kuppusamy, P. Simultaneous measurement of oxygen concentration and oxygen radicals in cellular and enzymatic reactions, Methods in Enzymology, 381, 747-762 (2004). [PubMed]
  6. Ilangovan, G., Zweier, J. L., & Kuppusamy, P. Mechanism of oxygen-induced EPR line broadening in lithium phthalocyanine microcrystals. J. Magn. Reson. 170, 42-48 (2004). [PubMed]
  7. Ilangovan, G., Osinbowale, S., Bratasz, A., Bonar, M., Cardounel, A. J., Zweier, J. L., and Kuppusamy, P. Heat-shock attenuates respiration of cardiomyocytes through upregulation of nitric oxide synthase. Am. J. Physiol. Cell Physiol. 287, C1472-1481 (2004). [PubMed]
  8. Ilangovan, G., Bratasz, A., Li, H., Schmalbrock, P., Zweier, J. L, Kuppusamy, P. In vivo measurement and imaging of tumor oxygenation using coembedded paramagnetic particulates. Magn. Reson. Med. 52, 650-657 (2004). [PubMed]
  9. Khramtsov, V.V, Grigor'ev, I.A., Foster, M.A., Lurie, D.J., Zweier J.L. and Kuppusamy, P. Spin pH and SH probes: enhancing functionality of EPR-based techniques, Journal of Spectroscopy, 18, 213-225 (2004).
  10. Kuppusamy P. EPR spectroscopy in biology and medicine (Forum Editorial). Antiox. Redox. Signal., 6, 583-585 (2004). [PubMed]
  11. Kuppusamy, P. and Zweier, J. L. Cardiac applications of EPR imaging. NMR in Biomedicine, 17, 226-239 (2004). [PubMed]
  12. Kutala, V. K., Parinandi, N. L., Pandian, R. P. and Kuppusamy, P. Simultaneous measurement of oxygenation in intracellular and extracellular compartments of lung microvascular endothelial cells. Antiox. Redox Signal. 6, 597-603 (2004). [PubMed]
  13. Kutala, V. K., Parinandi, N., Zweier, J. L., and Kuppusamy, P. Reaction of superoxide with trityl radical: Implications for the determination of superoxide by Spectrophotometry. Arch. Biochem. Biophys. 424, 81-88 (2004). [PubMed]
  14. Lustbader, J., Cirilli, M., Lin. C., Xu, H., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollack, S., Chaney, M., Trinchese, F., Liu, S., Gunn-Moore, F., Lue, LF, Walker, D. G., Kuppusamy, P., Zweier, J. L., Arancio, O., Stern, D., Yan, S. D., and Wu, H. ABAD directly links Ab to mitochondrial toxicity in Alzheimer’s disease. Science 304, 448-452 (2004). [PubMed]
  15. Mikuni, T., He, G., Petryakov, S., Fallouh, M., Deng, Y., Isihara, R., Kuppusamy, P., Tatsuta, M., and Zweier, J. L. In vivo detection of gastric cancer in rats by electron paramagnetic resonance imaging. Cancer Research 62, 6495-6502 (2004). [PubMed]
  16. Samouilov, A., Roubaud, V. M., Kuppusamy, P., and Zweier J. L. Kinetic analysis-based quantitation of free radical generation in EPR spin trapping. Anal. Biochem. 334, 145-154 (2004). [PubMed]
 
2003 back to top
  1. Deng, Y., He, G., Kuppusamy, P., and Zweier, J. L. Deconvolution algorithm based on automatic cutoff frequency selection for EPR imaging. Magn. Reson. Med., 50, 444-448 (2003). [PubMed]
  2. Ilangovan, G., Li, H., Zweier, J. L., and Kuppusamy, P. Effect of carbogen-breathing on redox status of RIF-1 tumor. Adv. Exp. Med. Biol. 510, 13-17 (2003). [PubMed]
  3. Liu, J. Q., Sham, J. S., Shimoda, L. A., Kuppusamy, P., and Sylvester, J. T. Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries. Am J Physiol Lung Cell Mol Physiol. 285, L322-L333 (2003). [PubMed]
  4. Pandian, R. P., Parinandi, N. L., Ilangovan, G., Zweier, J. L., and Kuppusamy, P. Novel particulate spin probe for targeted determination of oxygen in cells and tissues. Free Radic. Biol. Med. 35, 1138-1148 (2003). [PubMed]
  5. Pandian, R. P., Kutala, V. K., Parinandi, N. L., Zweier, J. L., and Kuppusamy, P. Measurement of oxygen consumption in mouse aortic endothelial cells using a microparticulate oximetry probe. Arch. Biochem.
  6. Biophys. 420, 169-175 (2003). [PubMed]
    Rizzi, C., Samouilov, A., Kutala, V., Parinandi, N. L., Zweier, J. L., and Kuppusamy, P. Application of a trityl-based radical for measuring superoxide. Free Radic. Biol. Med. 35, 1608-1618(2003). [PubMed]
  7. Velayutham, M., Li, H., Kuppusamy, P., and Zweier, J. L. Mapping ischemic risk region and necrosis in the isolated heart using EPR imaging. Magn. Reson. Med. 49, 1181-1187 (2003). [PubMed]
  8. Xu, K. Y. Kuppusamy, S. P., Wang, J. Q., Li, H., Cui, H., Dawson, T. M., Huang, P. L., Burnett, A. L., Kuppusamy, P., and Becker, L. C. Nitric oxide protects cardiac sarcolemmal membrane enzyme function and ion active transport against ischemia induced inactivation. J. Biol. Chem. 278, 41798-41803 (2003). [PubMed]
  9. Zweier, J. L., He, G., Samouilov, A., and Kuppusamy, P. EPR spectroscopy and imaging of oxygen: Application to the gastrointestinal tract. Adv. Exp. Med. Biol. 530, 123-131 (2003). [PubMed]
 
2002 back to top
  1. He, G., Deng, Y., Li, H., Kuppusamy, P., and Zweier, J. L. EPR/NMR co-imaging for anatomic registration of free radical images. Magn. Reson. Med. 47, 571-578 (2002). [PubMed]
  2. He, G., Samouilov, A., Kuppusamy, P. and Zweier, J. L. In vivo imaging of free radicals: Applications from mouse to man. Mol. Cell. Biochem. 234/235, 359-367 (2002). [PubMed]
  3. He, G., Evalappan, S. P., Hirata, H., Deng, Y., Petryakov, S., Kuppusamy, P., and Zweier, J. L. Mapping of the B1 field distribution of a surface coil resonator using EPR imaging. Magn. Reson. Med. 48, 1057-1062
  4. (2002). [PubMed]
    Ilangovan, G., Manivannan, A., Li, H., Yanagi, H., Zweier, J. L., and Kuppusamy, P. A naphthalocyanine-based EPR probe for localized measurements of tissue oxygenation. Free Radic. Biol. Med. 32, 139-147 (2002). [PubMed]
  5. Ilangovan, G., Li, H., Zweier, J.L., and Kuppusamy, P. In vivo measurement of tumor redox environment using EPR spectroscopy. Mol. Cell. Biochem. 234/235, 393-398 (2002). [PubMed]
  6. Ilangovan, G., Li, H., Zweier, J. L., Krishna, M. C., Mitchell, J. B., and Kuppusamy, P. In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: Effect of carbogen-breathing. Magn. Reson. Med. 48, 723-730 (2002). [PubMed]
  7. Ilangovan, G., Pal, R., Zweier, J. L., and Kuppusamy, P. Electrochemical preparation and EPR studies of lithium phthalocyanine. Part 4: Effect of nitric oxide. J. Phys. Chem. B 106, 11929-11935 (2002).
  8. Kuppusamy, P., Li, H., Ilangovan, G., Cardounel, A. J., Zweier, J. L., Yamada, K., Krishna, M. C., and Mitchell, J. B. Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels. Cancer Research, 62, 307-312 (2002). [PubMed]
  9. Kuppusamy, P. and Krishna, M. C. EPR imaging of tissue redox status. Curr. Topics in Biophys. 26, 29-34 (2002).
  10. Leonard, S. L., Mowrey, K., Pack, D., Shi, X., Castranova, V., Kuppusamy, P., and Vallyathan, V. In vivo bioassays of acute asbestosis and its correlation with ESR spectroscopy and imaging in redox status. Mol. Cell. Biochem. 234/235, 369-377 (2002). [PubMed]
  11. Li, H., Ma, L., Hsia, J.C., Zweier, J. L., and Kuppusamy, P. Poly-nitroxyl albumin (PNA) enhances myocardial infarction therapeutic effect of Tempol in rat hearts subjected to regional ischemia-reperfusion. Free Radic. Biol. Med. 32, 712-719 (2002). [PubMed]
  12. Li, H., Deng, Y., He, G., Kuppusamy, P., Lurie, D.J., and Zweier, J. L. Proton electron double resonance imaging of the in vivo distribution and clearance of a triarylmethyl radical in mice. Magn. Reson. Med. 48, 530-534 (2002). [PubMed]
  13. Li, Y., Seacat, A., Kuppusamy, P., Zweier, J. L., Yager, J. D., and Trush, M. A. Copper redox-dependent activation of 2-tert-butyl(1,4)hydroquinone: Formation of reactive oxygen species and induction of oxidative DNA damage in isolated DNA and cultured rat hepatocytes, Mutation Research 518, 123-133 (2002). [PubMed]
  14. Souza, H.P., Liu, X., Samouilov, A., Kuppusamy, P., Laurindo, F., Zweier, J. L. Quantitation of superoxide generation and substrate utilization by vascular NAD(P)H oxidase . Am. J. Physiol. Heart Circ. Physiol. 282, H466-H474 (2002). [PubMed]
  15. Yamada, K-I., Kuppusamy, P., English, S., Yoo. J., Irie, A., Subramanian, S., Mitchell, J. B., and Krishna, M. C. Feasibility and assessment of non-invasive in vivo redox status using electron paramagnetic resonance imaging. Acta Radiol. 43, 433-440 (2002). [PubMed]
  16. Zhou, L., Burnett, A. L., Huang, P. L., Becker, L. C. Kuppusamy, P., Kass, D. A. Donahue, J. K., Proud, D., Sham, J. S. K., Dawson, T. M. and Xu, K. Y. Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscle. Biochem. Biophys. Res. Comm. 294, 1030-1035 (2002). [PubMed]
 
2001 back to top
  1. Duilio, C., Ambrosio, G., Kuppusamy, P., DiPaula, A., Becker, L. C., Zweier, J. L. Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia. Am. J. Physiol. Heart Circ. Physiol. 280, H2649-H2657 (2001). [PubMed]
  2. Ellis, S., Velayutham, M., Sendhil Velan, S., Petersen, E.F., Zweier, J.L., Kuppusamy, P., and Spencer, R.G.S. EPR oxygen mapping [EPROM] of engineered cartilage grown in a hollow-fiber bioreactor. Magn. Reson. Med. 46, 819-826 (2001). [PubMed]
  3. He, G., Petryakov, S., Kuppusamy, P., Samouilov, A., and Zweier, J. L. EPR imaging: a technique enabling in vivo mapping of free radicals and redox metabolism in biochemical applications. Analyt. Sciences, 17, i507- i510 (2001).
  4. He, G., Samouilov, A., Kuppusamy, P., and Zweier, J. L. In vivo imaging of the distribution and metabolism of nitroxide radicals in human skin. J. Magn. Reson. 148, 155-164 (2001). [PubMed]
  5. He, G., Petryakov, S., Samouilov, A., Chzhan, M., Kuppusamy, P., and Zweier, J. L. Development of a resonator with automatic tuning and coupling capability to minimize sample motion noise for in vivo EPR spectroscopy J. Magn. Reson. 149, 218-227 (2001). [PubMed]
  6. Ilangovan, G., Li, H., Zweier, J. L., and Kuppusamy, P. Electrochemical preparation and EPR studies of lithium phthalocyanine. Part 3: Measurements of oxygen concentration in tissues and biochemical reactions J. Phys. Chem. B. 105, 5323-5330 (2001).
  7. Krishna, M. C., Devasahayam, N., Cook, J. A., Subramanian, S., Kuppusamy, P. and Mitchell, J. B. Electron paramagnetic resonance for small animal imaging applications. Inst. Lab. Animals Research J. 42, 209-218 (2001). [PubMed]
  8. Kuppusamy, P., Shankar, R. A., Roubaud, V. M., and Zweier, J. L. Whole body detection and imaging of nitric oxide generation in mice following cardiopulmonary arrest: Detection of intrinsic nitrosoheme complexes. Magn. Reson. Med. 45, 700-707(2001). [PubMed]
  9. Manivannan, A., Yanagi, H., Ilangovan, G, and Kuppusamy, P. Lithium naphthalocyanine as a new molecular radical probe for electron paramagnetic resonance oximetry, J. Magn. Magn. Mater. 233, L131-L135 (2001).
  10. Mitchell, J. B., Krishna, M. C., Kuppusamy, P., Cook, J. A., and Russo, A. Protection against oxidative stress by nitroxides. Exp. Biol. Med. 226, 620-621 (2001). [PubMed]
  11. Petryakov, S., Chzhan, M., Samouilov, A., He, G., Kuppusamy, P., and Zweier, J. L. A bridged loop–gap S-band surface resonator for topical EPR spectroscopy. J. Magn. Reson. 151, 124-128 (2001). [PubMed]
 
2000 back to top
  1. Ilangovan, G., Zweier, J. L., and Kuppusamy, P. Electrochemical preparation and EPR studies of lithium phthalocyanine: Evaluation of the nucleation and growth mechanism and evidence for potential-dependent phase formation. J. Phys. Chem. B. 104, 4047-4059 (2000).
  2. Ilangovan, G., Zweier, J. L., and Kuppusamy, P. Electrochemical preparation and EPR studies of lithium phthalocyanine. Part 2: Particle size-dependent line broadening by molecular oxygen and its implications as an oximetry Probe. J. Phys. Chem. B. 104, 9404-9410 (2000).
  3. Koscielniak, J., Devasahayam, N., Moni, M. S., Kuppusamy, P., Yamada, K., Mitchell, J. B., Krishna, M. C., and Subramanian, S. 300 MHz continuous wave electron paramagnetic resonance spectrometer for small animal in vivo imaging. Rev. Sci. Inst. 71, 4273-4281 (2000).
  4. Li, H., Xu, K. Y., Zhou, L., Kalai, T., Zweier, J. L., Hideg, K. and Kuppusamy, P. A pyrroline derivative of mexiletine offers marked protection against ischemia/reperfusion-induced myocardial contractile dysfunction. J. Pharmacol. Exp. Therap. 295, 563-571(2000). [PubMed]
  5. Shankar, R. A., Hideg, K., Zweier, J. L., and Kuppusamy, P. Targeted antioxidant properties of N-[(tetramethyl-3-pyrroline-3-carboxamido)propyl]phthalimide, and its nitroxide-metabolite in preventing postischemic myocardial injury. J. Pharmacol. Exp. Therap. 292, 838-845 (2000). [PubMed]
  6. Velan, S.S., Spencer, R. G., Zweier, J. L., and Kuppusamy, P. Electron paramagnetic resonance oxygen mapping [EPROM]: Direct visualization of oxygen concentration in tissues. Magn. Reson. Med. 43, 804-809 (2000). [PubMed]
  7. Zhang, S., Li, H., Ma, L., Trimble, C. E., Kuppusamy, P., Hsia, C. J. C., and Carden, D. L. Polynitroxyl-albumin (PNA) plus Tempol attenuate lung capillary leak elicited by prolonged intestinal ischemia and reperfusion. Free Radic. Biol. Med. 29, 42-50 (2000). [PubMed]
 
1999 back to top
  1. Chzhan, M., Kuppusamy, P., Samouilov, A., He, G., Zweier, J. L. A tunable reentrant resonator with transverse orientation of electric field for in vivo EPR spectroscopy. J. Magn. Reson. 137, 373-378 (1999). [PubMed]
  2. He, G., Shankar, R. A., Chzhan, M., Samouilov, A., Kuppusamy, P., and Zweier, J. L. Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging. Proc. Natl. Acad. Sci. USA 96, 4586-4591 (1999). [PubMed]
  3. Zweier, J. L., Samouilov, A., and Kuppusamy, P. Non-enzymatic nitric oxide synthesis in biological systems. Biochim. Biophys. Acta. 1411, 250-262 (1999). [PubMed]
 
1998 back to top
  1. Ha, H. C., Sirisoma, N. S., Kuppusamy, P., Zweier, J. L., Woster, P. M., Casero, Jr., R. A. The natural polyamine spermine functions directly as a free radical scavenger. Proc. Natl. Acad. Sci. USA 95, 11140-11145 (1998). [PubMed]
  2. Krishna, M. C., Kuppusamy, P., Afeworki, M., Cook, J. A., Subramanian, S., Mitchell, J. B. Development of functional electron paramagnetic resonance imaging. Breast Disease, 10, 209-220 (1998). [PubMed]
  3. Kuppusamy, P., Wang, P., Ma, L., Trimble, C. E., Hsia, C. J. C., and Zweier, J. L. In vivo topical EPR spectroscopy and imaging of the pharmacokinetics of nitroxide and polynitroxyl-albumin in mice. Magn. Reson. Med. 40, 1-6 (1998). [PubMed]
  4. Kuppusamy, P., Afeworki, M., Shankar, R. A., Deborah, C., Krishna, M. C., Hahn, S. M., Mitchell, J. B., and Zweier, J. L. In vivo electron paramagnetic resonance imaging of tumor heterogeneity and oxygenation in a murine tumor model. Cancer Research, 58, 1562-1568 (1998). [PubMed]
  5. Kuppusamy, P., Shankar, R. A., and Zweier, J. L. In vivo measurement of arterial and venous oxygenation in the rat using 3D spectral-spatial electron paramagnetic resonance imaging. Phys. Med. Biol. 43, 1837-1844 (1998). [PubMed]
  6. Li, Y., Zhu, H., Kuppusamy P., Roubaud, V. M., Zweier, J. L., Trush, M. A. Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. J. Biolog. Chem. 273, 2015-2023 (1998). [PubMed]
  7. Roubaud V. M., Sankarapandi S., Kuppusamy P, Tordo P., Zweier JL. Quantitative measurement of superoxide generation and oxygen consumption from leukocytes using electron paramagnetic resonance spectroscopy. Anal. Biochem. 257, 210-217 (1998). [PubMed]
  8. Samouilov, A., Kuppusamy, P. and Zweier, J. L. Evaluation of the magnitude and rate of nitric oxide production from nitrite in biological systems. Arch. Biochem. Biophys. 357, 1-7 (1998). [PubMed]
  9. Zweier, J. L., Chzhan, M., Samouilov, A., and Kuppusamy, P. Electron paramagnetic resonance imaging of the rat heart. Phys. Med. Biolog. 43, 1823-1835 (1998). [PubMed]
 
1997 back to top
  1. Kuppusamy, P., Wang, P., and Zweier, J. L. High resolution electron paramagnetic resonance imaging of biological samples with a single line paramagnetic label. Magn. Reson. Med. 37, 479-483 (1997). [PubMed]
  2. Roubaud, V., Sankarapandi, S., Kuppusamy, P., Tardo, P., and Zweier, J. L. Quantitative Measurement of superoxide generation using the spin trap 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide. Analyt. Biochem. 247, 404-411 (1997). [PubMed]
  3. Seacat, A.M., Kuppusamy, P., Zweier, J. L., and Yager, J. D. Electron spin resonance identification of free radicals formed from the oxidation of catechol estrogens by copper (II). Arch. Biochem. Biophys. 347, 45-52 (1997). [PubMed]
  4. Vallyathan, V., Leonard, S., Kuppusamy, P., Pack, D., Chzhan, M., Sanders, S. P., and Zweier, J. L. Oxidative stress in silicosis: Evidence for the enhanced clearance of free radicals from whole lungs. Mol. Cell. Biochem. 168, 125-132 (1997). [PubMed]
 
1996 back to top
  1. Kuppusamy, P., Ohnishi, S. T., Numagami, Y., Ohnishi, T., and Zweier, J. L. Imaging of nitric oxide generation in the brain. Res. Chem. Interm. 22, 605-613 (1996).
  2. Kuppusamy, P., and Zweier, J. L. A forward subtraction procedure for removing hyperfine artifacts in electron paramagnetic resonance imaging. Magn. Reson. Med., 35, 316-322 (1996). [PubMed]
  3. Kuppusamy, P., and Zweier, J. L. Hyperfine artifacts in electron paramagnetic resonance imaging. Res. Chem. Interm. 22, 593-604 (1996).
  4. Kuppusamy, P., Chzhan, M., Wang, P., and Zweier, J. L. Three-dimensional gated EPR imaging of the beating heart: Time-resolved measurements of free radical distribution during the cardiac contractile cycle. Magn. Reson. Med., 35, 323-328 (1996). [PubMed]
  5. Kuppusamy, P., Wang, P., Zweier, J.L., Krishna, M. C., Mitchell, J. B., Ma, L., Trimble, C.E., and Hsia, C.J. EPR imaging of rat heart with nitroxide and a polynitroxylated albumin. Biochemistry 35, 7051-7057 (1996). [PubMed]
  6. Kuppusamy, P., Wang, P., Samouilov, A., and Zweier, J. L. Spatial mapping of nitric oxide in the ischemic heart using electron paramagnetic resonance imaging. Magn. Reson. Med. 36, 212-218 (1996). [PubMed]
  7. Kuppusamy, P., and Zweier, J. L. Electron paramagnetic resonance imaging of biological samples. EPR Specialist Vignettes, EPR Newsletter, Vol 8, 1996.
  8. Li, Y., Kuppusamy, P., Zweier, J. L., and Trush, M. A. Role of Cu, Zn-superoxide dismutase (Cu,ZnSOD) in xenobiotic activation: I. Chemical reactions involved in the Cu, ZnSOD-accelerated oxidation of the benzene metabolite, 1,4-hydroxyquinone. Mol. Pharmacol. 49, 404-411 (1996). [PubMed]
  9. Li, Y., Kuppusamy, P., Zweier, J. L., and Trush, M. A. Role of Cu, Zn-superoxide dismutase (Cu,ZnSOD) in xenobiotic activation: II. Biological effects resulting from the Cu,ZnSOD-accelerated oxidation of the benzene metabolite, 1,4-hydroxyquinone. Mol. Pharmacol. 49, 412-421 (1996). [PubMed]
  10. Primiano, T., Kensler, T. W., Kuppusamy, P., Zweier, J.L., and Sutter, T. R. Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones. Carcinogenesis. 17, 2291-2296 (1996). [PubMed]
  11. Schauer, D. A., Desrosiers, M. F., Kuppusamy, P., and Zweier, J. L. Radiation dosimetry of an accidental overexposure using EPR spectrometry and imaging of human bone. Appl. Radiat. Isotop. 47, 1345-50, (1996). [PubMed]
  12. Serrano, C. V., Mikhail, E. A., Wang, P., Noble, B., Kuppusamy, P. and Zweier, J. L. Superoxide and hydrogen peroxide induce CD-18 mediated adhesion in the post ischemic heart. Biochim. Biophys. Acta, 1310, 5 (1996). [PubMed]
  13. Zweier, J. L., Wang, P., Chzhan, M., and Kuppusamy, P. Spatial and spectral-spatial imaging of free radicals and oxygen in the heart. Res. Chem. Interm. 22, 615-624 (1996).
 
1995 back to top
  1. Chzhan, M., Kuppusamy, P., and Zweier, J. L. Development of an electronically tunable L-band resonator for EPR spectroscopy and imaging of biological samples. J. Magn. Reson. B 108, 67-72 (1995). [PubMed]
  2. Desrosiers, M. F., Burlinska, G., Kuppusamy, P., Zweier, J. L., Yaczko, D.M., Auteri, F.P., McClelland, M. R., Dick, C.E., and McLaughlin, W. L. Research and development activities in electron paramagnetic resonance dosimetry. Radiat. Phys. Chem. 46, 1181-1184 (1995).
  3. Kuppusamy, P., and Zweier, J. L. EPR imaging of free radicals in the perfused heart. Curr. Topics in Biophys. 18, 3-13 (1995).
  4. Kuppusamy, P., Chzhan, M., and Zweier, J. L. Development and optimization of three-dimensional spatial EPR imaging for biological organs and tissues. J. Magn. Reson. B106, 122-130 (1995). [PubMed]
  5. Kuppusamy, P., Chzhan, M., Samouilov, A., Wang, P., and Zweier, J. L. Mapping the spin-density and lineshape distribution of free radicals in the heart using 4D spectral-spatial EPR imaging. J. Magn. Reson. B107, 116-125 (1995). [PubMed]
  6. Kuppusamy, P., Chzhan, M., and Zweier, J. L. 3D and 4D electron paramagnetic resonance imaging of the rat heart. Magn. Reson. Med. (Japan) 6, 59-61 (1995).
  7. Kuppusamy, P., Wang, P., and Zweier, J. L. Three-dimensional spatial EPR imaging of the rat heart. Magn. Reson. Med. 34, 99-105 (1995). [PubMed]
  8. Kuppusamy, P., Ohnishi, S. T., Numagami, Y., Ohnishi, T., and Zweier, J. L. Three-dimensional imaging of nitric oxide production in the rat brain subjected to ischemia-hypoxia. J. Cereb. Blood Flow Metab. 15, 899-903 (1995). [PubMed]
  9. Kuppusamy, P., Wang, P., and Zweier, J. L. Evaluation of nitroxides for the study of myocardial metabolism and oxygenation. Magn. Reson. Chem. 33, S123-S128 (1995).
  10. Li, Y., Kuppusamy, P., Zweier, J. L., and Trush, M. A. ESR evidence for the generation of reactive oxygen species from the copper mediated oxidation of the benzene metabolite, hydroquinone: Role in DNA damage. Chemico-biological Interactions 94, 101-120 (1995). [PubMed]
  11. Yan, S. D., Yan, S. F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Yen, S. H., Smith, M. A., Perry, G., Nawroth, P., Godman, G. C., Zweier, J. L., and Stern, D. Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid-b peptide. Nature Medicine 1, 693-699 (1995). [PubMed]
  12. Zweier, J. L., and Kuppusamy, P. EPR spectroscopy of free radicals in the perfused heart. Curr. Topics in Biophys. 18, 14-25 (1995).
  13. Zweier, J. L, Wang, P., Samouilov, A., and Kuppusamy, P. Enzyme independent formation of nitric oxide in biological tissues. Nature Medicine, 1, 804-809 (1995). [PubMed]
  14. Zweier, J. L., Wang, P., and Kuppusamy, P. Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy. J. Biolog. Chem., 270, 304-307 (1995). [PubMed]
 
1994 back to top
  1. Chen, K., Ng, C. E., Zweier, J. L., Kuppusamy, P., Glickson, J. D., and Swartz, H. M. Measurement of the intracellular concentration of oxygen in a cell perfusion system. Magn. Reson. Med. 31, 1-5 (1994). [PubMed]
  2. Kuppusamy, P., Chzhan, M., Vij, K., Shteynbuk, M., Lefer, D. J., Gianella, E., and Zweier, J. L. Three dimensional spectral-spatial EPR imaging of free radicals in the heart: A technique forimaging tissue metabolism and oxygenation. Proc. Natl. Acad. Sci. USA , 91, 3388-3392 (1994). [PubMed]
  3. Sanders, S. P., Harrison, S. J., Kuppusamy, P., Sylvester, J. T., and Zweier, J. L. A comparative study of EPR spin trapping and cytochrome c reduction techniques for the measurement of superoxide anions. Free Rad. Biolog. Med. 16, 753-761(1994). [PubMed]
  4. Zweier, J. L., Chzhan, M., Ewert, U., Schneider, G., and Kuppusamy, P. Development of a highly sensitive probe for measuring oxygen in biological tissues. J. Magn. Reson. B 105, 52-57(1994). [PubMed]
  5. Zweier, J. L., Kuppusamy, P., Thompson-Gorman, S., Klunk, D., and Lutty, G. A. Measurement and characterization of free radical generation in reoxygenated human endothelial cells. Am. J. Physiol. (Cell Physiology) 266, C700-C708 (1994). [PubMed]
  6. Zweier, J. L., and Kuppusamy, P. In vivo EPR spectroscopy of free radicals in the heart. Environ. Health Perspectives, 102, 45-51(1994). [PubMed]
  7. Zweier, J. L., Broderick, R., Kuppusamy, P., Thompson-Gorman, S., and Lutty, G. A. Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation. J. Biolog. Chem. 269, 24156-24162 (1994). [PubMed]
 
1993 back to top
  1. Shandelya, S. M. L., Kuppusamy, P., Weisfeldt, M. L., and Zweier, J. L. Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Circulation, 87, 536-546 (1993).
  2. Shandelya, S. M. L., Kuppusamy, P., Herskowitz, A., Weisfeldt, M.L., and Zweier, J. L. Soluble complement receptor type 1 inhibits the complement pathway and prevents contractile failure in the postischemic heart: Evidence that complement activation is required for neutrophil-mediated reperfusion injury. Circulation, 88, 2812-2826 (1993).
  3. Sanders, S. P., Zweier, J. L., Kuppusamy, P., Harrison, S. J., Bassett, D. J., Gabrielson, E. W., and Sylvester, J. T. Hyperoxic sheep pulmonary microvascular endothelial cells generate free radicals via mitochondrial electron transport. J. Clin. Invest, 91, 46-52 (1993).
  4. Chzhan, M., Shteynbuk, M., Kuppusamy, P., and Zweier, J. L. An optimized L-band resonator for EPR imaging of biological samples. J. Magn. Reson. A105, 49-53 (1993).
  5. Ambrosio, G., Zweier, J. L., Duilio, C., Kuppusamy, P., Santoro, G., Elia, P., Tritto, I., Cirillo, P., Condorelli, M., Chiariello, M., and Flaherty, J. T. Evidence that mitochondrial respiration is a source of potentially toxic oxygen Free radicals in intact rabbit hearts subjected to ischemia and reflow. J. Biolog. Chem., 268, 18532-18541 (1993).
  6. Lefer, D. J., Shandelya, S. M. L., Serrano Jr., C. V., Becker, L. C., Kuppusamy, P., and Zweier, J. L. Cardioprotective actions of monoclonal antibody against CD-18 in myocardial ischemia-reperfusion injury. Circulation, 88, 1779-1787 (1993).
 
1992 back to top
  1. Kuppusamy, P., and Zweier, J. L. Identification and quantitation of free radicals and paramagnetic centers from complex multicomponent EPR spectra. Appl. Radiat. Isotopes. 44, 367-372 (1992).
  2. Gabrielson, E. W., Kuppusamy, P., Povey, A. C., Zweier, J. L., and Harris, C. C. Measurement of neutrophil activation and epidermal cell toxicity by palytoxin and 12-o-tetradcanoylphorbol-13-acetate. Carcinogenesis, 13, 395-401 (1992).
  3. Povey, A. C., Wilson, V. L., Zweier, J. L., Kuppusamy, P., O'Neil, I. K., and Harris, C. C. Detection by 32P-postlabeling of DNA adducts induced by free radicals and unsaturated aldehydes formed during the aerobic decomposition of fecapentaene-12. Carcinogenesis, 13, 395-401 (1992).
  4. Grill, H. P., Zweier, J. L., Kuppusamy, P., Weisfeldt, M. L., and Flaherty, J. T. Direct measurement of myocardial free radical generation in an in-vivo model: Effects of post-ischemic reperfusion and treatment with human recombinant superoxide dismutase. J. Amer. Coll. Cardio. 20, 1604-1611 (1992).
 
1991 back to top
  1. Guyton, K. Z., Bhan, P., Kuppusamy, P., Zweier, J. L., Trush, M. A., and Kensler, T. W. Free radical derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide: Expanded role for electrophiles in multistage carcinogenesis. Proc. Nat. Acad. Sci. USA, 88, 946-950 (1991).
  2. Swauger, J. E., Dolan, P. M., Zweier, J. L., Kuppusamy, P., Kensler, T. W. Role of benzoyloxyl radical in DNA damage mediated by benzoyl peroxide. Chemical Research in Toxicology, 4, 228-233 (1991).
  3. Kukreja, R. C., Kearns, A. A., Zweier, J. L., Kuppusamy, P., Hess, M. L. Singlet oxygen interaction with Ca2+-ATPase of cardiac sarcoplasmic reticulum. Circulation Research. 69, 1003-1014 (1991).
  4. Zweier, J. L., Thompson-Gorman, S., and Kuppusamy, P. Measurement of oxygen concentrations in the intact heart using electron paramagnetic resonance spectroscopy: A technique for measuring oxygen concentrations in situ. J. Bioenerg., and Biomem., 23, 855-871 (1991).
 
1990 back to top
  1. Levy, A., Kuppusamy, P., and Rifkind, J. M. Multiple heme pocket subconformations of methemoglobin associated with distal histidine interactions. Biochem., 29, 9311-9316 (1990).
  2. Zweier, J. L., and Kuppusamy, P. Study of free radicals in the intact beating heart using low frequency EPR spectroscopy. Phys. Med., 7, 1-9 (1990).
 
1989 back to top
  1. Rajalakshmi, A, Radha, A., Seshasayee, M., Kuppusamy, P., and Manoharan, P. T. Crystal and molecular structure of tetraethyl ammonium bis(stilbene-1,2-dithiolato)nickelate(III). Zeitschr. Kristallogr. 187, 159-164 (1989).
  2. Kuppusamy, P., and Zweier, J. L. Characterization of free radical generation by xanthine oxidase: Evidence for hydroxyl radical generation. J. Biolog. Chem., 264, 9880-9884 (1989).
  3. Zweier, J. L., Kuppusamy, P., Williams, R., Rayburn, B. K., Smith, D., Weisfeldt, M. L., and Flaherty, J. T. Measurement and characterization of postischemic free radical generation in the isolated perfused heart. J. Biolog. Chem., 264, 18890-18895 (1989).
  4. Zweier, J. L., and Kuppusamy, P. Electron paramagnetic resonance studies of free radicals in the perfused heart. Phys. Med., 5, 289-296 (1989).
  5. Zweier, J. L., Duke, S. S., Kuppusamy, P., Sylvester, J. T., and Gabrielson, E. Electron paramagnetic resonance evidence that cellular oxygen toxicity is caused by the generation of superoxide and hydroxyl free radicals. FEBS Lett., 252, 12-16 (1989).
 
1988 back to top
  1. Radha, A., Seshasayee, M. and Kuppusamy, P. Structure of bis[1,2-bis(diphenylphosphino ethylene)] iodocobalt(II) tetraphenylborate. Acta Cryst. C44, 1008-1011 (1988).
  2. Zweier, J. L., Kuppusamy, P., and Lutty, G. A. Measurement of endothelial cell free radical generation: Evidence for a central mechanism of free radical injury in post ischemic tissues. Proc. Natl. Acad. Sci. USA, 85, 4046-4050 (1988).
  3. Zweier, J. L., and Kuppusamy, P. Electron paramagnetic resonance measurements of free radicals in the intact beating heart: A technique for detection and characterization of free radicals in whole biological tissues. Proc. Nat. Acad. Sci. USA, 85, 5703-5707 (1988).
 
1987 back to top
  1. Kuppusamy, P., and Manoharan, P. T. Magnetic properties of some exchanged coupled [Ni(mnt)2]- dimers. Proc. Ind. Acad. Sci., 98, 115-129 (1987).
 
1985 back to top
  1. Kuppusamy, P., Mahadevan, C., Seshasayee, M., and Manoharan, P. T. Crystal and molecular structure of N-methylphenazinium bis(maleonitriledithiolato) nickelate(III). J. Cryst. Spect. Res., 15, 359-376 (1985).
  2. Kuppusamy, P., and Manoharan, P. T. Exchange interactions in [NMe4]2[Cu(mnt)2]: A quasi 1-d weak exchange system. Inorg. Chem., 24, 3053-3057 (1985).
  3. Kuppusamy, P., Venkatalakshmi, N., and Manoharan, P. T. Structure of N-methylphenazinium bis(maleonitriledithiolato) gold(III). J. Cryst. Spect. Res., 15, 629-641 (1985).
  4. Kuppusamy, P., and Manoharan, P. T. Anisotropic exchange interaction in tetra-n-butylammonium bis(stilbene-1,2-dithiolato)nickelate(III). Chem. Phys. Lett., 188, 159-163 (1985).
  5. Kuppusamy, P., and Manoharan, P. T. Hyperfine and exchange interactions in tetraethylammonium bis(maleonitriledithiolato)cuprate(II). J. Ind. Chem. Soc., 63, 95-101 (1985).
  6. Mahadevan, C., Kuppusamy, P., Seshasayee, M., and Manoharan, P. T. Crystal and molecular structure of N-methylphenazinium bis(benzene-1,2-dithiolato)nickel(III). J. Cryst. Spec. Res., 15, 305-316 (1985).
 
1984 back to top
  1. Kuppusamy, P., Ramakrishna, B. L., and Manoharan, P. T. EPR, magnetic and structural investigations on the weak exchange Heisenberg linear chain [(NMP)2][Cu(mnt)2]. Inorg. Chem., 23, 3886-3892 (1984).
  2. Kuppusamy, P., Ramakrishna, B. L., and Manoharan, P. T. Exchange interactions in some low-dimensional metal dithiolene complexes. Proc. Ind. Acad. Scien., 93, 977-1001 (1984).
  3. Mahadevan, C., Kuppusamy, P., Seshasayee, M., and Manoharan, P. T. Crystal and molecular structure of tetra-n-butylammonium bis(stilbene-1,2-dithiolato)nickelate(III). J. Cryst. Spec. Res., 4, 177-190 (1984).
 
1983 back to top
  1. Kuppusamy, P., and Manoharan, P. T. Spin correlation functions in the weak exchange Heisenberg linear chain [(NMP)2][Cu(mnt)2]. Bull. Mag. Res., 5, 207 (1983).
  2. Ramakrishna, B. L., Kuppusamy, P., Manoharan, P. T., and Hunziker, M. Structural and magnetic investigations on the charge transfer ion radical salt, [TMPD][Ni(mnt)2]. J. Phys. Colloq., 44, 1409-1412 (1983).
  3. Mahadevan, C., Kuppusamy, P., Murthy, B. V. R., Seshasayee, M., and Manoharan, P. T. Structure of trimethylammonium bis(maleonitriledithiolato)nickelate(III). Acta Cryst., C39, 1335-1343 (1983).
 
Book Chapters back to top
  1. Zweier, J. L., Kuppusamy, P., Shandelya, M. L., Thompson-Gorman, S., Weisman, H. F., Fearon, D. T., and Weisfeldt, M. L. Electron paramagnetic resonance measurements of free radical generation in isolated cells and whole tissues. The Molecular Basis of Oxidative Damage by Leukocytes (Editor: Jesaitis/Dratz), CRC Press, Inc. pp. 181-202 (1992).
  2. Kuppusamy, P. and Zweier, J. L. Study of free radical generation in isolated cells and whole tissues using electron paramagnetic resonance spectroscopy. Cellular Membrane: A Key to Disease Processes (Edited by Ohnishi/Ohnishi) Chapter 10, CRC Press, Inc., 1992.
  3. Zweier, J. L. and Kuppusamy, P. Principles of electron paramagnetic resonance spectroscopy for measurement of free radicals in biological tissues. In 'Nitric Oxide in Transplant Rejection and Antitumor Defense', (Eds. Luckiewicz and Zweier) Chapter 1, Kluwer Academic Publishers, 1998.
  4. Kuppusamy, P., and Zweier, J. L., EPR imaging of free radicals in biological systems. In 'Nitric Oxide in Transplant Rejection and Antitumor Defense', (Eds. Luckiewicz and Zweier) Chapter 2, Kluwer Academic Publishers, 1998.

  5. Zweier, J. L., Samouilov, A., and Kuppusamy, P. Enzyme-independent formation of nitric oxide in tissues. In 'Nitric Oxide in Transplant Rejection and Antitumor Defense', (Eds. Luckiewicz and Zweier) Chapter 3, Kluwer Academic Publishers, 1998.

  6. Kuppusamy, P., Ohnishi, S. T., and Zweier, J. L. Electron paramagnetic resonance imaging of nitric oxide in tissues. In 'Nitric Oxide in Transplant Rejection and Antitumor Defense', (Eds. Luckiewicz and Zweier) Chapter 4, Kluwer Academic Publishers, 1998.
  7. Zweier, J. L., Chzhan, M., Samouilov, A., and Kuppusamy, P. EPR imaging of the rat heart. In Magnetic Resonance in Medicine (Japan) 1998.
  8. Zweier, J. L. and Kuppusamy, P. EPR imaging of the rat heart. In Spatially Resolved Magnetic Resonance (Eds. Blumler, P., Blumich, B., Botto, R. and Fukushima, E., Wiley-VCH, New York (1999).
  9. Mitchell, J. B., Russo, A., Kuppusamy, P. and Krishna, M. C. Radiation, radicals, and images. In Reactive Oxygen Species, Annals of the New York Acad. Sci. Vol 899, 28-43(2000).
  10. Krishna, M. C., Kuppusamy, P., Mitchell, J. B. Protective properties of stable nitroxide free radicals against oxidative stress. In "Free Radicals in Toxicology and Drug Metabolism", (2000).
  11. Krishna, M. C., Subramanian, S., Kuppusamy, P., Mitchell, J. B. Magnetic resonance imaging for in vivo assessment of tissue oxygen concentration, Seminars in Radiation Oncology, Vol. 11, 58-69 (2001).
  12. Kuppusamy, P., and Chzhan, M., and Zweier, J. L. Principles of EPR imaging - Hardware and Software. In Biological Magnetic Resonance (Ed. Berliner, L. J.) Vol 18, Chapter 6. Kluwer Academic Publishers (2003).
  13. Zweier, J. L. Samouilov, A., and Kuppusamy, P. Cardiac applications of EPR spectroscopy and imaging In Biological Magnetic Resonance (Ed. Berliner, L. J.) Vol 18, Chapter 16. Kluwer Academic Publishers (2003).
Last update: Feburary 2009. All rights reserved 2008-2010.