Karuppaiyah Selvendiran       

Karuppaiyah Selvendiran, PhD
Research Scientist
Department of Internal medicine
Dorothy M. Davis Heart & lung Research Institute
Ohio State University Medical Center
420 W 12th Avenue, Room 114
Columbus OH 43210
Phone: (614) 688-5927
Email: selvendiran.karuppaiyah@osumc.edu
 
Research Interests
My research interest is directed towards: i). Activation of the tumor suppressor gene PTEN, and inhibition of STAT3 signaling in ovarian cancer, ii.) Role of STAT3 in hypoxic ovarian cancer and implications of HBOT as adjuvant therapy iii.) Role of Fatty acid synthase (FAS) in ovarian cancer and identification of FAS inhibitors, iv) Use of novel synthetic curcumin analog compounds for ovarian cancer therapy.
 
Current Projects
  • Safe, targeted antitumor therapeutics (STAT3 inhibitors) for ovarian cancer
  • Role of FAS in ovarian cancer
 
Selected Publications
  • Selvendiran K, Koga H, Ueno T, Yoshida T, Maeyama M, Torimura T, Yano H, Kojiro M, Sata M (2006). Luteolin promotes degradation in signal transducer and activator of transcription (STAT3) in human hepatoma cells: an implication for anti-tumor potential of flavonoids. Cancer Research. 66: 4826 – 4834.
  • Selvendiran K, Weir N.M., Kutala VK, Tong L, Vishwanath S, Rajaram M, Tridandapani S, Anant S, Kuppusamy P (2007). Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biology & Therapy. 6:178-184.
  • Selvendiran K, Bratasz A, Tong L, and Kuppusamy P (2007). NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 7: 81-88.
  • Selvendiran K, Tong L, Vishwanath S, Bratasz A, Trigg NJ, Kutala VK, Hideg K, Kuppusamy P (2007). EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by inhibiting PTEN proteasomal degradation. J. Biol. Chem. 282: 28609-28618.
  • Bratasz A, Selvendiran K, Wasowicz T, Bobko A, Khramtsov VV, Ignarro LJ, Kuppusamy P (2008). NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols. Journal of Translational Medicine. 26: 9-20.
 
NIH Biosketch
Last update: Feburary 2009. All rights reserved 2008-2010.